Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression

Emerging studies have shown that the expression of AR splice variants (ARv) lacking ligand-binding domain is associated with castrate-resistant prostate cancer (CRPC) and higher risk of tumor metastasis and recurrence. Nuclear export protein XPO1 regulates the nuclear localization of many proteins i...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Aboukameel, Amro, Muqbil, Irfana, Baloglu, Erkan, Senapedis, William, Landesman, Yosef, Argueta, Christian, Kauffman, Michael, Chang, Hua, Kashyap, Trinayan, Shacham, Sharon, Neggers, Jasper E., Daelemans, Dirk, Heath, Elisabeth I., Azmi, Asfar S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219671/
https://ncbi.nlm.nih.gov/pubmed/30450161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26239
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