A structurally tunable DNA-based extracellular matrix

Por Aldaye, Faisal A., Senapedis, William T., Silver, Pamela A., Way, Jeffrey C.
Publicado em 2010

Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain

Por Senapedis, William T., Kennedy, Caleb J., Boyle, Patrick M., Silver, Pamela A.
Publicado em 2011

Nucleo-cytoplasmic transport as a therapeutic target of cancer

Por Gravina, Giovanni Luca, Senapedis, William, McCauley, Dilara, Baloglu, Erkan, Shacham, Sharon, Festuccia, Claudio
Publicado no J Hematol Oncol (2014)

Dual and specific inhibition of NAMPT and PAK4 by KPT-9274 decreases kidney cancer growth

Por Aboud, Omran Abu, Chen, Ching-Hsien, Senapedis, William, Baloglu, Erkan, Argueta, Christian, Weiss, Robert H.
Publicado no Mol Cancer Ther (2016)

A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth

Por Rane, Chetan, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Crochiere, Marsha, Das-Gupta, Soumyasri, Minden, Audrey
Publicado no Sci Rep (2017)

Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds

Por Crochiere, Marsha, Kashyap, Trinayan, Kalid, Ori, Shechter, Sharon, Klebanov, Boris, Senapedis, William, Saint-Martin, Jean-Richard, Landesman, Yosef
Publicado no BMC Cancer (2015)

XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells

Por Taylor‐Kashton, Cheryl, Lichtensztejn, Daniel, Baloglu, Erkan, Senapedis, William, Shacham, Sharon, Kauffman, Michael G., Kotb, Rami, Mai, Sabine
Publicado no J Cell Physiol (2016)

Novel p21-activated kinase 4 (PAK4) allosteric modulators overcome drug resistance and stemness in pancreatic ductal adenocarcinoma

Por Aboukameel, Amro, Muqbil, Irfana, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Philip, Philip A., Mohammad, Ramzi M., Azmi, Asfar S.
Publicado no Mol Cancer Ther (2016)

Novel Small Molecule XPO1/CRM1 Inhibitors Induce Nuclear Accumulation of TP53, Phosphorylated MAPK and Apoptosis in Human Melanoma Cells

Por Yang, Jennifer, Bill, Matthew A., Young, Gregory S., La Perle, Krista, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Senapedis, William, Kashyap, Trinayan, Saint-Martin, Jean-Richard, Kendra, Kari, Lesinski, Gregory B.
Publicado em 2014

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

Por Azmi, Asfar S., Muqbil, Irfana, Wu, Jack, Aboukameel, Amro, Senapedis, William, Baloglu, Erkan, Bollig-Fischer, Aliccia, Dyson, Gregory, Kauffman, Michael, Landesman, Yosef, Shacham, Sharon, Philip, Philip A., Mohammad, Ramzi M.
Publicado no Sci Rep (2015)

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell dea...

Por Kashyap, Trinayan, Argueta, Christian, Aboukameel, Amro, Unger, Thaddeus John, Klebanov, Boris, Mohammad, Ramzi M., Muqbil, Irfana, Azmi, Asfar S., Drolen, Claire, Senapedis, William, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Publicado no Oncotarget (2016)

Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma

Por Fulciniti, Mariateresa, Martinez-Lopez, Joaquin, Senapedis, William, Oliva, Stefania, Lakshmi Bandi, Rajya, Amodio, Nicola, Xu, Yan, Szalat, Raphael, Gulla, Annamaria, Samur, Mehmet K., Roccaro, Aldo, Linares, Maria, Cea, Michele, Baloglu, Erkan, Argueta, Christian, Landesman, Yosef, Shacham, Sharon, Liu, Siyuan, Schenone, Monica, Wu, Shiaw-Lin, Karger, Barry, Prabhala, Rao, Anderson, Kenneth C., Munshi, Nikhil C.
Publicado no Blood (2017)

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

Por Kim, Jimi, McMillan, Elizabeth, Kim, Hyun Seok, Venkateswaran, Niranjan, Makkar, Gurbani, Rodriguez-Canales, Jaime, Villalobos, Pamela, Neggers, Jasper Edgar, Mendiratta, Saurabh, Wei, Shuguang, Landesman, Yosef, Senapedis, William, Baloglu, Erkan, Chow, Chi-Wan B., Frink, Robin E., Gao, Boning, Roth, Michael, Minna, John D., Daelemans, Dirk, Wistuba, Ignacio I., Posner, Bruce A., Scaglioni, PierPaolo, White, Michael A.
Publicado no Nature (2016)