Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and therapy resistant malignancy. Mutant K-Ras, found in >90% of refractory PDAC, acts as a molecular switch activating Rho GTPase signaling that in turn promotes a plethora of pro-survival molecules and oncogenic microRNAs. We invest...

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Detalhes bibliográficos
Publicado no:Small GTPases
Main Authors: Mohammad, Ramzi M., Li, Yiwei, Muqbil, Irfana, Aboukameel, Amro, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Philip, Philip A., Azmi, Asfar S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Brief Report - Commissioned
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748371/
https://ncbi.nlm.nih.gov/pubmed/28641032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2017.1329694
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