PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors

Pancreatic neuroendocrine tumors (PNET) remain an unmet clinical need. In this study, we show that targeting both nicotinamide phosphoribosyltransferase (NAMPT) and p21-activated kinase 4 (PAK4) could become a synthetic lethal strategy for PNET. The expression of PAK4 and NAMPT was found to be highe...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Cancers (Basel)
Glavni autori: Mpilla, Gabriel, Aboukameel, Amro, Muqbil, Irfana, Kim, Steve, Beydoun, Rafic, Philip, Philip A., Mohammad, Ramzi M., Kamgar, Mandana, Shidham, Vinod, Senapedis, William, Baloglu, Erkan, Li, Jing, Dyson, Gregory, Xue, Yue, El-Rayes, Bassel, Azmi, Asfar S.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966587/
https://ncbi.nlm.nih.gov/pubmed/31795447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121902
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items