PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors

Pancreatic neuroendocrine tumors (PNET) remain an unmet clinical need. In this study, we show that targeting both nicotinamide phosphoribosyltransferase (NAMPT) and p21-activated kinase 4 (PAK4) could become a synthetic lethal strategy for PNET. The expression of PAK4 and NAMPT was found to be highe...

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Publicado en:Cancers (Basel)
Main Authors: Mpilla, Gabriel, Aboukameel, Amro, Muqbil, Irfana, Kim, Steve, Beydoun, Rafic, Philip, Philip A., Mohammad, Ramzi M., Kamgar, Mandana, Shidham, Vinod, Senapedis, William, Baloglu, Erkan, Li, Jing, Dyson, Gregory, Xue, Yue, El-Rayes, Bassel, Azmi, Asfar S.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966587/
https://ncbi.nlm.nih.gov/pubmed/31795447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121902
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