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Specific Inhibition of the Nuclear Exporter Exportin-1 Attenuates Kidney Cancer Growth

PURPOSE: Despite the advent of FDA-approved therapeutics to a limited number of available targets (kinases and mTOR), PFS of kidney cancer (RCC) has been extended only one to two years due to the development of drug resistance. Here, we evaluate a novel therapeutic for RCC which targets the exportin...

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Опубликовано в: :PLoS One
Главные авторы: Wettersten, Hiromi I., Landesman, Yosef, Friedlander, Sharon, Shacham, Sharon, Kauffman, Michael, Weiss, Robert H.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252068/
https://ncbi.nlm.nih.gov/pubmed/25461627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113867
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