Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels

Autosomal-dominant polycystic kidney disease (ADPKD) is a progressive, proliferative renal disease. Kidneys from ADPKD patients are characterized by the presence of cysts that are marked by enhanced proliferation and apoptosis of renal tubular epithelial cells. Current treatment of this disease is s...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Tan, Matthew, Wettersten, Hiromi I., Chu, Kristy, Huso, David L., Watnick, Terry, Friedlander, Sharon, Landesman, Yosef, Weiss, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254973/
https://ncbi.nlm.nih.gov/pubmed/25234309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00406.2014
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