CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury

Acute kidney injury (AKI) is common and urgently requires new preventative therapies. Expression of a cyclin-dependent kinase (CDK) inhibitor transgene protects against AKI, suggesting that manipulating the tubular epithelial cell cycle may be a viable therapeutic strategy. Broad spectrum small mole...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: DiRocco, Derek P., Bisi, John, Roberts, Patrick, Strum, Jay, Wong, Kwok-Kin, Sharpless, Norman, Humphreys, Benjamin D.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2013
Sujets:
Call for Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920026/
https://ncbi.nlm.nih.gov/pubmed/24338822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00475.2013
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