Dual CDK4/CDK6 Inhibition Induces Cell Cycle Arrest and Senescence in Neuroblastoma

PURPOSE: Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and mortality. Recently, a number of cell cycle proteins, particularly those within the Cyclin D/CDK4/CDK6/RB network, have been shown to exert oncogenic roles in neuroblastoma, suggesting that their therapeut...

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Auteurs principaux: Rader, JulieAnn, Russell, Mike R., Hart, Lori S., Nakazawa, Michael S., Belcastro, Lili T., Martinez, Daniel, Li, Yimei, Carpenter, Erica L., Attiyeh, Edward F., Diskin, Sharon J., Kim, Sunkyu, Parasuraman, Sudha, Caponigro, Giordano, Schnepp, Robert W., Wood, Andrew C., Pawel, Bruce, Cole, Kristina A., Maris, John M.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844928/
https://ncbi.nlm.nih.gov/pubmed/24045179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1675
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