COMBINATION THERAPY TARGETING THE CHK1 AND WEE1 KINASES DEMONSTRATES THERAPEUTIC EFFICACY IN NEUROBLASTOMA

Neuroblastoma is uniquely sensitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us to examine downstream effectors of this pathway and identify mitotic regulator Wee1 as an additional therapeutic target in this disease. Wee1 was overexpressed in both neuroblastoma ce...

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Detalhes bibliográficos
Main Authors: Russell, Mike R., Levin, Kirill, Rader, JulieAnn, Belcastro, Lili, Li, Yimei, Martinez, Daniel, Pawel, Bruce, Shumway, Stuart D., Maris, John M., Cole, Kristina A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548976/
https://ncbi.nlm.nih.gov/pubmed/23135916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2669
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