Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition

BACKGROUND: Inhibition of kinases involved in the DNA damage response sensitizes cells to genotoxic agents by abrogating checkpoint-induced cell cycle arrest. CHK1 and WEE1 act in a pathway upstream of CDK1 to inhibit cell cycle progression in response to damaged DNA. Therapeutic targeting of either...

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Библиографические подробности
Главные авторы: Guertin, Amy D, Martin, Melissa M, Roberts, Brian, Hurd, Melissa, Qu, Xianlu, Miselis, Nathan R, Liu, Yaping, Li, Jing, Feldman, Igor, Benita, Yair, Bloecher, Andrew, Toniatti, Carlo, Shumway, Stuart D
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
Предметы:
Primary Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517755/
https://ncbi.nlm.nih.gov/pubmed/23148684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-12-45
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