Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress

The therapeutic efficacy of nucleoside analogues, e.g. gemcitabine, against cancer cells can be augmented by inhibitors of checkpoint kinases, including Wee1, ATR, and Chk1. We have compared the chemosensitizing effect of these inhibitors in cells derived from pancreatic cancer, a tumor entity where...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Saini, Priyanka, Li, Yizhu, Dobbelstein, Matthias
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537000/
https://ncbi.nlm.nih.gov/pubmed/25965828
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