Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

Pharmacological inhibition of the cell cycle regulatory kinase Wee1 represents a promising strategy to eliminate cancer cells. Wee1 inhibitors cooperate with chemotherapeutics, e. g. nucleoside analogues, pushing malignant cells from S phase towards premature mitosis and death. However, considerable...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Li, Yizhu, Saini, Priyanka, Sriraman, Anusha, Dobbelstein, Matthias
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2015
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Priority Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741697/
https://ncbi.nlm.nih.gov/pubmed/26431163
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