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Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma

BACKGROUND: Malignant melanoma has an increasing incidence rate and the metastatic disease is notoriously resistant to standard chemotherapy. Loss of cell cycle checkpoints is frequently found in many cancer types and makes the cells reliant on compensatory mechanisms to control progression. This fe...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:BMC Cancer
Κύριοι συγγραφείς: Magnussen, Gry Irene, Emilsen, Elisabeth, Giller Fleten, Karianne, Engesæter, Birgit, Nähse-Kumpf, Viola, Fjær, Roar, Slipicevic, Ana, Flørenes, Vivi Ann
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2015
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460948/
https://ncbi.nlm.nih.gov/pubmed/26054341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1474-8
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