High Expression of Wee1 Is Associated with Poor Disease-Free Survival in Malignant Melanoma: Potential for Targeted Therapy

Notoriously resistant malignant melanoma is one of the most increasing forms of cancer worldwide; there is thus a precarious need for new treatment options. The Wee1 kinase is a major regulator of the G(2)/M checkpoint, and halts the cell cycle by adding a negative phosphorylation on CDK1 (Tyr15). A...

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Bibliografiske detaljer
Main Authors: Magnussen, Gry Irene, Holm, Ruth, Emilsen, Elisabeth, Rosnes, Anne Katrine Ree, Slipicevic, Ana, Flørenes, Vivi Ann
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373567/
https://ncbi.nlm.nih.gov/pubmed/22719872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038254
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