Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma

BACKGROUND: Malignant melanoma has an increasing incidence rate and the metastatic disease is notoriously resistant to standard chemotherapy. Loss of cell cycle checkpoints is frequently found in many cancer types and makes the cells reliant on compensatory mechanisms to control progression. This fe...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Magnussen, Gry Irene, Emilsen, Elisabeth, Giller Fleten, Karianne, Engesæter, Birgit, Nähse-Kumpf, Viola, Fjær, Roar, Slipicevic, Ana, Flørenes, Vivi Ann
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460948/
https://ncbi.nlm.nih.gov/pubmed/26054341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1474-8
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