RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

Neuroblastoma is a childhood cancer that is often fatal despite intense multimodality therapy. In an effort to identify therapeutic targets for this disease, we performed a comprehensive loss-of-function screen of the protein kinome. Thirty kinases showed significant cellular cytotoxicity when deple...

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Bibliografiske detaljer
Main Authors: Cole, Kristina A., Huggins, Jonathan, Laquaglia, Michael, Hulderman, Chase E., Russell, Mike R., Bosse, Kristopher, Diskin, Sharon J., Attiyeh, Edward F., Sennett, Rachel, Norris, Geoffrey, Laudenslager, Marci, Wood, Andrew C., Mayes, Patrick A., Jagannathan, Jayanti, Winter, Cynthia, Mosse, Yael P., Maris, John M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044382/
https://ncbi.nlm.nih.gov/pubmed/21289283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012351108
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