RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

Neuroblastoma is a childhood cancer that is often fatal despite intense multimodality therapy. In an effort to identify therapeutic targets for this disease, we performed a comprehensive loss-of-function screen of the protein kinome. Thirty kinases showed significant cellular cytotoxicity when deple...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Cole, Kristina A., Huggins, Jonathan, Laquaglia, Michael, Hulderman, Chase E., Russell, Mike R., Bosse, Kristopher, Diskin, Sharon J., Attiyeh, Edward F., Sennett, Rachel, Norris, Geoffrey, Laudenslager, Marci, Wood, Andrew C., Mayes, Patrick A., Jagannathan, Jayanti, Winter, Cynthia, Mosse, Yael P., Maris, John M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044382/
https://ncbi.nlm.nih.gov/pubmed/21289283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012351108
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars