RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

Neuroblastoma is a childhood cancer that is often fatal despite intense multimodality therapy. In an effort to identify therapeutic targets for this disease, we performed a comprehensive loss-of-function screen of the protein kinome. Thirty kinases showed significant cellular cytotoxicity when deple...

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Main Authors: Cole, Kristina A., Huggins, Jonathan, Laquaglia, Michael, Hulderman, Chase E., Russell, Mike R., Bosse, Kristopher, Diskin, Sharon J., Attiyeh, Edward F., Sennett, Rachel, Norris, Geoffrey, Laudenslager, Marci, Wood, Andrew C., Mayes, Patrick A., Jagannathan, Jayanti, Winter, Cynthia, Mosse, Yael P., Maris, John M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044382/
https://ncbi.nlm.nih.gov/pubmed/21289283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012351108
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