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Genome-Wide Linkage Analysis to Identify Genetic Modifiers of ALK Mutation Penetrance in Familial Neuroblastoma

BACKGROUND: Neuroblastoma (NB) is an important childhood cancer with a strong genetic component related to disease susceptibility. Approximately 1% of NB cases have a positive family history. Following a genome-wide linkage analysis and sequencing of candidate genes in the critical region, we identi...

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Detalhes bibliográficos
Main Authors: Devoto, Marcella, Specchia, Claudia, Laudenslager, Marci, Longo, Luca, Hakonarson, Hakon, Maris, John, Mossé, Yael
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136385/
https://ncbi.nlm.nih.gov/pubmed/21734404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000324843
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