RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

Neuroblastoma is a childhood cancer that is often fatal despite intense multimodality therapy. In an effort to identify therapeutic targets for this disease, we performed a comprehensive loss-of-function screen of the protein kinome. Thirty kinases showed significant cellular cytotoxicity when deple...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Cole, Kristina A., Huggins, Jonathan, Laquaglia, Michael, Hulderman, Chase E., Russell, Mike R., Bosse, Kristopher, Diskin, Sharon J., Attiyeh, Edward F., Sennett, Rachel, Norris, Geoffrey, Laudenslager, Marci, Wood, Andrew C., Mayes, Patrick A., Jagannathan, Jayanti, Winter, Cynthia, Mosse, Yael P., Maris, John M.
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2011
الموضوعات:
Biological Sciences
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044382/
https://ncbi.nlm.nih.gov/pubmed/21289283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012351108
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