XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose

XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective Inhibitor of Nuclear Export (SINE) compounds block nuclear export by inhibiting XPO1. The first SINE compoun...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Crochiere, Marsha L., Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2017
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746399/
https://ncbi.nlm.nih.gov/pubmed/29299164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22801
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