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XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose

XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective Inhibitor of Nuclear Export (SINE) compounds block nuclear export by inhibiting XPO1. The first SINE compoun...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Crochiere, Marsha L., Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746399/
https://ncbi.nlm.nih.gov/pubmed/29299164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22801
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