Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents

INTRODUCTION: The goal of this study was to examine the effects of selinexor, an inhibitor of exportin-1 mediated nuclear export, on DNA damage repair and to evaluate the cytotoxic effects of selinexor in combination with DNA damaging agents (DDAs) in cancer cells. RESULTS: Selinexor reduced the exp...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kashyap, Trinayan, Argueta, Christian, Unger, Thaddeus, Klebanov, Boris, Debler, Sophia, Senapedis, William, Crochiere, Marsha L., Lee, Margaret S., Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089403/
https://ncbi.nlm.nih.gov/pubmed/30112106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25637
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