XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose

XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective Inhibitor of Nuclear Export (SINE) compounds block nuclear export by inhibiting XPO1. The first SINE compoun...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Crochiere, Marsha L., Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746399/
https://ncbi.nlm.nih.gov/pubmed/29299164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22801
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