Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer

Chromosome maintenance region 1 (CRM1) also called Exportin 1 (Xpo1), a protein found elevated in pancreatic ductal adenocarcinoma (PDAC), blocks tumor suppressor protein (TSP) function through constant nuclear export. Earlier we had shown that targeting CRM1 by our newly developed specific inhibito...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gao, Jiankun, Azmi, Asfar S., Aboukameel, Amro, Kauffman, Michael, Shacham, Sharon, Abou-Samra, Abdul-Badi, Mohammad, Ramzi M.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2014
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116494/
https://ncbi.nlm.nih.gov/pubmed/24899509
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