Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice

BACKGROUND & AIMS: Tumor suppressor proteins are inactivated by many different mechanisms, including nuclear exclusion by chromosome region maintenance (CRM)-1. Increased tumor levels of CRM-1 have been correlated with poor prognosis of patients with pancreatic cancer, making it a therapeutic ta...

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מידע ביבליוגרפי
Main Authors: Azmi, Asfar S., Aboukameel, Amro, Bao, Bin, Sarkar, Fazlul H., Philip, Philip A., Kauffman, Michael, Shacham, Sharon, Mohammad, Ramzi M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594519/
https://ncbi.nlm.nih.gov/pubmed/23089203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.10.036
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