Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis

Chromosomal rearrangements resulting in the fusion of TMPRSS2, an androgen-regulated gene, and the ETS family transcription factor ERG occur in over half of prostate cancers. However, the mechanism by which ERG promotes oncogenic gene expression and proliferation remains incompletely understood. Her...

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Publicado no:Mol Cell
Main Authors: Sandoval, Gabriel J., Pulice, John L., Pakula, Hubert, Schenone, Monica A., Takeda, David Y., Pop, Marius, Boulay, Gaylor, Williamson, Kaylyn E., McBride, Matthew J., Pan, Joshua, Pierre, Roodolph St., Hartman, Emily, Garraway, Levi A., Carr, Steven A., Rivera, Miguel N., Li, Zhe, Ronco, Lucienne, Hahn, William C., Kadoch, Cigall
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140332/
https://ncbi.nlm.nih.gov/pubmed/30078722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.040
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