Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis

Chromosomal rearrangements resulting in the fusion of TMPRSS2, an androgen-regulated gene, and the ETS family transcription factor ERG occur in over half of prostate cancers. However, the mechanism by which ERG promotes oncogenic gene expression and proliferation remains incompletely understood. Her...

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Publicat a:Mol Cell
Autors principals: Sandoval, Gabriel J., Pulice, John L., Pakula, Hubert, Schenone, Monica A., Takeda, David Y., Pop, Marius, Boulay, Gaylor, Williamson, Kaylyn E., McBride, Matthew J., Pan, Joshua, Pierre, Roodolph St., Hartman, Emily, Garraway, Levi A., Carr, Steven A., Rivera, Miguel N., Li, Zhe, Ronco, Lucienne, Hahn, William C., Kadoch, Cigall
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140332/
https://ncbi.nlm.nih.gov/pubmed/30078722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.040
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