Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes

[Image: see text] We show that natural products target proteins with a high number of protein−protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential...

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Detaylı Bibliyografya
Asıl Yazarlar: Dančík, Vlado, Seiler, Kathleen Petri, Young, Damian W., Schreiber, Stuart L., Clemons, Paul A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2010
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898216/
https://ncbi.nlm.nih.gov/pubmed/20565092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja102798t
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