Tankyrase Polymerization Is Controlled by Its Sterile Alpha Motif and Poly(ADP-Ribose) Polymerase Domains

Por De Rycker, Manu, Price, Carolyn M.
Publicado em 2004

Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization.

Por De Rycker, Manu, Venkatesan, Ranga N, Wei, Chao, Price, Carolyn M
Publicado em 2003

Challenges and recent progress in drug discovery for tropical diseases

Por De Rycker, Manu, Baragaña, Beatriz, Duce, Suzanne L., Gilbert, Ian H.
Publicado no Nature (2018)

Regulatory Domain Selectivity in the Cell-Type Specific PKN-Dependence of Cell Migration

Por Lachmann, Sylvie, Jevons, Amy, De Rycker, Manu, Casamassima, Adele, Radtke, Simone, Collazos, Alejandra, Parker, Peter J.
Publicado em 2011

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes

Por De Rycker, Manu, O'Neill, Sandra, Joshi, Dhananjay, Campbell, Lorna, Gray, David W., Fairlamb, Alan H.
Publicado em 2012

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade

Por De Rycker, Manu, Thomas, John, Riley, Jennifer, Brough, Stephen J., Miles, Tim J., Gray, David W.
Publicado no PLoS Negl Trop Dis (2016)

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Por Torrie, Leah S., Zuccotto, Fabio, Robinson, David A., Gray, David W., Gilbert, Ian H., De Rycker, Manu
Publicado no PLoS One (2019)

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery

Por MacLean, Lorna M., Thomas, John, Lewis, Michael D., Cotillo, Ignacio, Gray, David W., De Rycker, Manu
Publicado no PLoS Negl Trop Dis (2018)

Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment

Por Zmuda, Filip, Shepherd, Sharon M., Ferguson, Michael A. J., Gray, David W., Torrie, Leah S., De Rycker, Manu
Publicado no Antimicrob Agents Chemother (2019)

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intrac...

Por Nühs, Andrea, De Rycker, Manu, Manthri, Sujatha, Comer, Eamon, Scherer, Christina A., Schreiber, Stuart L., Ioset, Jean-Robert, Gray, David W.
Publicado no PLoS Negl Trop Dis (2015)

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Por Zmuda, Filip, Sastry, Lalitha, Shepherd, Sharon M., Jones, Deuan, Scott, Alison, Craggs, Peter D., Cortes, Alvaro, Gray, David W., Torrie, Leah S., De Rycker, Manu
Publicado no Antimicrob Agents Chemother (2019)

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

Por Patterson, Stephen, Wyllie, Susan, Stojanovski, Laste, Perry, Meghan R., Simeons, Frederick R. C., Norval, Suzanne, Osuna-Cabello, Maria, De Rycker, Manu, Read, Kevin D., Fairlamb, Alan H.
Publicado em 2013

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Por Thomas, Michael G., De Rycker, Manu, Cotillo Torrejon, Ignacio, Thomas, John, Riley, Jennifer, Spinks, Daniel, Read, Kevin D., Miles, Tim J., Gilbert, Ian H., Wyatt, Paul G.
Publicado no Bioorg Med Chem Lett (2018)

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Por De Rycker, Manu, Hallyburton, Irene, Thomas, John, Campbell, Lorna, Wyllie, Susan, Joshi, Dhananjay, Cameron, Scott, Gilbert, Ian H., Wyatt, Paul G., Frearson, Julie A., Fairlamb, Alan H., Gray, David W.
Publicado em 2013

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Por De Rycker, Manu, Hallyburton, Irene, Thomas, John, Campbell, Lorna, Wyllie, Susan, Joshi, Dhananjay, Cameron, Scott, Gilbert, Ian H., Wyatt, Paul G., Frearson, Julie A., Fairlamb, Alan H., Gray, David W.
Publicado no Antimicrob Agents Chemother (2014)

Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need

Por Field, Mark C., Horn, David, Fairlamb, Alan H., Ferguson, Michael A. J., Gray, David W., Read, Kevin D., De Rycker, Manu, Torrie, Leah S., Wyatt, Paul G., Wyllie, Susan, Gilbert, Ian H.
Publicado no Nat Rev Microbiol (2017)

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Por Cleghorn, Laura A. T., Albrecht, Sébastien, Stojanovski, Laste, Simeons, Frederick R. J., Norval, Suzanne, Kime, Robert, Collie, Iain T., De Rycker, Manu, Campbell, Lorna, Hallyburton, Irene, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.
Publicado no J Med Chem (2015)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

Por Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A T, Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A, Gray, David W, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H
Publicado no ChemMedChem (2015)

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

Por Torrie, Leah S., Robinson, David A., Thomas, Michael G., Hobrath, Judith V., Shepherd, Sharon M., Post, John M., Ko, Eun-Jung, Ferreira, Rafael Alves, Mackenzie, Claire J., Wrobel, Karolina, Edwards, Darren P., Gilbert, Ian H., Gray, David W., Fairlamb, Alan H., De Rycker, Manu
Publicado no ACS Infect Dis (2020)

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

Por Torrie, Leah S., Brand, Stephen, Robinson, David A., Ko, Eun Jung, Stojanovski, Laste, Simeons, Frederick R. C., Wyllie, Susan, Thomas, John, Ellis, Lucy, Osuna-Cabello, Maria, Epemolu, Ola, Nühs, Andrea, Riley, Jennifer, MacLean, Lorna, Manthri, Sujatha, Read, Kevin D., Gilbert, Ian H., Fairlamb, Alan H., De Rycker, Manu
Publicado no ACS Infect Dis (2017)