Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

per Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Publicat 2010

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis

per Wyllie, Susan, Patterson, Stephen, Stojanovski, Laste, Simeons, Frederick R. C., Norval, Suzanne, Kime, Robert, Read, Kevin D., Fairlamb, Alan H.
Publicat 2012

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

per Patterson, Stephen, Wyllie, Susan, Norval, Suzanne, Stojanovski, Laste, Simeons, Frederick RC, Auer, Jennifer L, Osuna-Cabello, Maria, Read, Kevin D, Fairlamb, Alan H
Publicat a eLife (2016)

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

per Patterson, Stephen, Wyllie, Susan, Stojanovski, Laste, Perry, Meghan R., Simeons, Frederick R. C., Norval, Suzanne, Osuna-Cabello, Maria, De Rycker, Manu, Read, Kevin D., Fairlamb, Alan H.
Publicat 2013

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

per Barini, Erica, Miccoli, Ageo, Tinarelli, Federico, Mulholland, Katie, Kadri, Hachemi, Khanim, Farhat, Stojanovski, Laste, Read, Kevin D., Burness, Kerry, Blow, Julian J., Mehellou, Youcef, Muqit, Miratul M. K.
Publicat a Chembiochem (2018)

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

per Venigalla, Ram K C, McGuire, Victoria A, Clarke, Rosemary, Patterson-Kane, Janet C, Najafov, Ayaz, Toth, Rachel, McCarthy, Pierre C, Simeons, Frederick, Stojanovski, Laste, Arthur, J Simon C
Publicat 2013

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

per Cleghorn, Laura A. T., Albrecht, Sébastien, Stojanovski, Laste, Simeons, Frederick R. J., Norval, Suzanne, Kime, Robert, Collie, Iain T., De Rycker, Manu, Campbell, Lorna, Hallyburton, Irene, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.
Publicat a J Med Chem (2015)

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

per Bayliss, Tracy, Robinson, David A., Smith, Victoria C., Brand, Stephen, McElroy, Stuart P., Torrie, Leah S., Mpamhanga, Chido, Norval, Suzanne, Stojanovski, Laste, Brenk, Ruth, Frearson, Julie A., Read, Kevin D., Gilbert, Ian H., Wyatt, Paul G.
Publicat a J Med Chem (2017)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

per Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A T, Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A, Gray, David W, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H
Publicat a ChemMedChem (2015)

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

per Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A, Luksch, Torsten, Smith, Alasdair, Torrie, Leah S, McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T, Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H
Publicat a ChemMedChem (2015)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

per Harrison, Justin R., Brand, Stephen, Smith, Victoria, Robinson, David A., Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S., Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Publicat a J Med Chem (2018)

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

per Torrie, Leah S., Brand, Stephen, Robinson, David A., Ko, Eun Jung, Stojanovski, Laste, Simeons, Frederick R. C., Wyllie, Susan, Thomas, John, Ellis, Lucy, Osuna-Cabello, Maria, Epemolu, Ola, Nühs, Andrea, Riley, Jennifer, MacLean, Lorna, Manthri, Sujatha, Read, Kevin D., Gilbert, Ian H., Fairlamb, Alan H., De Rycker, Manu
Publicat a ACS Infect Dis (2017)

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

per Corpas-Lopez, Victoriano, Moniz, Sonia, Thomas, Michael, Wall, Richard J., Torrie, Leah S., Zander-Dinse, Dorothea, Tinti, Michele, Brand, Stephen, Stojanovski, Laste, Manthri, Sujatha, Hallyburton, Irene, Zuccotto, Fabio, Wyatt, Paul G., De Rycker, Manu, Horn, David, Ferguson, Michael A. J., Clos, Joachim, Read, Kevin D., Fairlamb, Alan H., Gilbert, Ian H., Wyllie, Susan
Publicat a ACS Infect Dis (2018)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

per Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
Publicat 2011

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

per Thomas, Michael G., De Rycker, Manu, Wall, Richard J., Spinks, Daniel, Epemolu, Ola, Manthri, Sujatha, Norval, Suzanne, Osuna-Cabello, Maria, Patterson, Stephen, Riley, Jennifer, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Naylor, Claire, Fiandor, Jose M., Wyatt, Paul G., Marco, Maria, Wyllie, Susan, Read, Kevin D., Miles, Timothy J., Gilbert, Ian H.
Publicat a J Med Chem (2020)

Automated design of ligands to polypharmacological profiles

per Besnard, Jérémy, Ruda, Gian Filippo, Setola, Vincent, Abecassis, Keren, Rodriguiz, Ramona M., Huang, Xi-Ping, Norval, Suzanne, Sassano, Maria F., Shin, Antony I., Webster, Lauren A., Simeons, Frederick R.C., Stojanovski, Laste, Prat, Annik, Seidah, Nabil G., Constam, Daniel B., Bickerton, G. Richard, Read, Kevin D., Wetsel, William C., Gilbert, Ian H., Roth, Bryan L., Hopkins, Andrew L.
Publicat 2012

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Tre...

per Brand, Stephen, Norcross, Neil R., Thompson, Stephen, Harrison, Justin R., Smith, Victoria C., Robinson, David A., Torrie, Leah S., McElroy, Stuart P., Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C., van Aalten, Daan, Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Publicat a J Med Chem (2014)

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

per Thomas, Michael, Brand, Stephen, De Rycker, Manu, Zuccotto, Fabio, Lukac, Iva, Dodd, Peter G., Ko, Eun-Jung, Manthri, Sujatha, McGonagle, Kate, Osuna-Cabello, Maria, Riley, Jennifer, Pont, Caterina, Simeons, Frederick, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna, Elisabet, Fiandor, Jose M., Martin, Julio, Wyatt, Paul G., Miles, Timothy J., Read, Kevin D., Marco, Maria, Gilbert, Ian H.
Publicat a J Med Chem (2021)

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

per Baragaña, Beatriz, Norcross, Neil R., Wilson, Caroline, Porzelle, Achim, Hallyburton, Irene, Grimaldi, Raffaella, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C., Wyatt, Paul G., Delves, Michael J., Meister, Stephan, Duffy, Sandra, Avery, Vicky M., Winzeler, Elizabeth A., Sinden, Robert E., Wittlin, Sergio, Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Waterson, David, Campbell, Simon F., Willis, Paul, Read, Kevin D., Gilbert, Ian H.
Publicat a J Med Chem (2016)

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

per Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D., Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F., Fiandor, Jose M., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Miles, Timothy J.
Publicat a RSC Med Chem (2020)