Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

por Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Publicado 2010

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis

por Wyllie, Susan, Patterson, Stephen, Stojanovski, Laste, Simeons, Frederick R. C., Norval, Suzanne, Kime, Robert, Read, Kevin D., Fairlamb, Alan H.
Publicado 2012

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

por Patterson, Stephen, Wyllie, Susan, Norval, Suzanne, Stojanovski, Laste, Simeons, Frederick RC, Auer, Jennifer L, Osuna-Cabello, Maria, Read, Kevin D, Fairlamb, Alan H
Publicado en eLife (2016)

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

por Patterson, Stephen, Wyllie, Susan, Stojanovski, Laste, Perry, Meghan R., Simeons, Frederick R. C., Norval, Suzanne, Osuna-Cabello, Maria, De Rycker, Manu, Read, Kevin D., Fairlamb, Alan H.
Publicado 2013

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

por Barini, Erica, Miccoli, Ageo, Tinarelli, Federico, Mulholland, Katie, Kadri, Hachemi, Khanim, Farhat, Stojanovski, Laste, Read, Kevin D., Burness, Kerry, Blow, Julian J., Mehellou, Youcef, Muqit, Miratul M. K.
Publicado en Chembiochem (2018)

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

por Venigalla, Ram K C, McGuire, Victoria A, Clarke, Rosemary, Patterson-Kane, Janet C, Najafov, Ayaz, Toth, Rachel, McCarthy, Pierre C, Simeons, Frederick, Stojanovski, Laste, Arthur, J Simon C
Publicado 2013

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

por Cleghorn, Laura A. T., Albrecht, Sébastien, Stojanovski, Laste, Simeons, Frederick R. J., Norval, Suzanne, Kime, Robert, Collie, Iain T., De Rycker, Manu, Campbell, Lorna, Hallyburton, Irene, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.
Publicado en J Med Chem (2015)

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

por Bayliss, Tracy, Robinson, David A., Smith, Victoria C., Brand, Stephen, McElroy, Stuart P., Torrie, Leah S., Mpamhanga, Chido, Norval, Suzanne, Stojanovski, Laste, Brenk, Ruth, Frearson, Julie A., Read, Kevin D., Gilbert, Ian H., Wyatt, Paul G.
Publicado en J Med Chem (2017)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

por Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A T, Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A, Gray, David W, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H
Publicado en ChemMedChem (2015)

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

por Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A, Luksch, Torsten, Smith, Alasdair, Torrie, Leah S, McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T, Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H
Publicado en ChemMedChem (2015)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

por Harrison, Justin R., Brand, Stephen, Smith, Victoria, Robinson, David A., Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S., Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Publicado en J Med Chem (2018)

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

por Torrie, Leah S., Brand, Stephen, Robinson, David A., Ko, Eun Jung, Stojanovski, Laste, Simeons, Frederick R. C., Wyllie, Susan, Thomas, John, Ellis, Lucy, Osuna-Cabello, Maria, Epemolu, Ola, Nühs, Andrea, Riley, Jennifer, MacLean, Lorna, Manthri, Sujatha, Read, Kevin D., Gilbert, Ian H., Fairlamb, Alan H., De Rycker, Manu
Publicado en ACS Infect Dis (2017)

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

por Corpas-Lopez, Victoriano, Moniz, Sonia, Thomas, Michael, Wall, Richard J., Torrie, Leah S., Zander-Dinse, Dorothea, Tinti, Michele, Brand, Stephen, Stojanovski, Laste, Manthri, Sujatha, Hallyburton, Irene, Zuccotto, Fabio, Wyatt, Paul G., De Rycker, Manu, Horn, David, Ferguson, Michael A. J., Clos, Joachim, Read, Kevin D., Fairlamb, Alan H., Gilbert, Ian H., Wyllie, Susan
Publicado en ACS Infect Dis (2018)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

por Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
Publicado 2011

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

por Thomas, Michael G., De Rycker, Manu, Wall, Richard J., Spinks, Daniel, Epemolu, Ola, Manthri, Sujatha, Norval, Suzanne, Osuna-Cabello, Maria, Patterson, Stephen, Riley, Jennifer, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Naylor, Claire, Fiandor, Jose M., Wyatt, Paul G., Marco, Maria, Wyllie, Susan, Read, Kevin D., Miles, Timothy J., Gilbert, Ian H.
Publicado en J Med Chem (2020)

Automated design of ligands to polypharmacological profiles

por Besnard, Jérémy, Ruda, Gian Filippo, Setola, Vincent, Abecassis, Keren, Rodriguiz, Ramona M., Huang, Xi-Ping, Norval, Suzanne, Sassano, Maria F., Shin, Antony I., Webster, Lauren A., Simeons, Frederick R.C., Stojanovski, Laste, Prat, Annik, Seidah, Nabil G., Constam, Daniel B., Bickerton, G. Richard, Read, Kevin D., Wetsel, William C., Gilbert, Ian H., Roth, Bryan L., Hopkins, Andrew L.
Publicado 2012

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Tre...

por Brand, Stephen, Norcross, Neil R., Thompson, Stephen, Harrison, Justin R., Smith, Victoria C., Robinson, David A., Torrie, Leah S., McElroy, Stuart P., Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C., van Aalten, Daan, Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Publicado en J Med Chem (2014)

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

por Thomas, Michael, Brand, Stephen, De Rycker, Manu, Zuccotto, Fabio, Lukac, Iva, Dodd, Peter G., Ko, Eun-Jung, Manthri, Sujatha, McGonagle, Kate, Osuna-Cabello, Maria, Riley, Jennifer, Pont, Caterina, Simeons, Frederick, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna, Elisabet, Fiandor, Jose M., Martin, Julio, Wyatt, Paul G., Miles, Timothy J., Read, Kevin D., Marco, Maria, Gilbert, Ian H.
Publicado en J Med Chem (2021)

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

por Baragaña, Beatriz, Norcross, Neil R., Wilson, Caroline, Porzelle, Achim, Hallyburton, Irene, Grimaldi, Raffaella, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C., Wyatt, Paul G., Delves, Michael J., Meister, Stephan, Duffy, Sandra, Avery, Vicky M., Winzeler, Elizabeth A., Sinden, Robert E., Wittlin, Sergio, Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Waterson, David, Campbell, Simon F., Willis, Paul, Read, Kevin D., Gilbert, Ian H.
Publicado en J Med Chem (2016)

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

por Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D., Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F., Fiandor, Jose M., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Miles, Timothy J.
Publicado en RSC Med Chem (2020)