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Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
[Image: see text] Trypanosoma bruceiN-myristoyltransferase (TbNMT) is an attractive therapeutic target for the treatment of human African trypanosomiasis (HAT). From previous studies, we identified pyrazole sulfonamide, DDD85646 (1), a potent inhibitor of TbNMT. Although this compound represents an...
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Опубликовано в: : | J Med Chem |
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Главные авторы: | , , , , , , , , , , , , , , , , , , , , |
Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
American Chemical
Society
2014
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Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4269550/ https://ncbi.nlm.nih.gov/pubmed/25412409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500809c |
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