Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

A resazurin-based cell viability assay was developed for phenotypic screening of the LOPAC 1280 ‘library of pharmacologically active compounds’ against bloodstream forms of Trypanosoma brucei in vitro identifying 33 compounds with EC(50) values <1 μM. Counter-screening vs. normal diploid human fi...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Format: Artigo
Langue:Inglês
Publié: Elsevier Science 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025325/
https://ncbi.nlm.nih.gov/pubmed/20696141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.07.038
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