Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Screening of the Sigma–Aldrich Library of Pharmacologically Active Compounds (LOPAC) against cultured Trypanosoma brucei, the causative agent of African sleeping sickness, resulted in the identification of a number of compounds with selective antiproliferative activity over mammalian cells. These in...

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Detalhes bibliográficos
Main Authors: Smith, Victoria C, Cleghorn, Laura A T, Woodland, Andrew, Spinks, Daniel, Hallyburton, Irene, Collie, Iain T, Yi Mok, N, Norval, Suzanne, Brenk, Ruth, Fairlamb, Alan H, Frearson, Julie A, Read, Kevin D, Gilbert, Ian H, Wyatt, Paul G
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2011
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Full Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229842/
https://ncbi.nlm.nih.gov/pubmed/21834094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100278
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