Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

nork Robinson, David A., Wyatt, Paul G.
Argitaratua izan da Acta Crystallogr F Struct Biol Commun (2015)

Target assessment for antiparasitic drug discovery

nork Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Argitaratua 2007

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

nork Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D, Fairlamb, Alan H
Argitaratua 2011

The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis

nork Urich, Robert, Grimaldi, Raffaella, Luksch, Torsten, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G.
Argitaratua 2014

Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

nork König, Janine, Wyllie, Susan, Wells, Geoffrey, Stevens, Malcolm F., Wyatt, Paul G., Fairlamb, Alan H.
Argitaratua 2011

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

nork Patterson, Stephen, Jones, Deuan C, Shanks, Emma J, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H
Argitaratua 2009

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

nork Urich, Robert, Wishart, Grant, Kiczun, Michael, Richters, André, Tidten-Luksch, Naomi, Rauh, Daniel, Sherborne, Brad, Wyatt, Paul G., Brenk, Ruth
Argitaratua 2013

A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes

nork Galvin, Brendan D., Li, Zhiru, Villemaine, Estelle, Poole, Catherine B., Chapman, Melissa S., Pollastri, Michael P., Wyatt, Paul G., Carlow, Clotilde K. S.
Argitaratua 2014

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

nork Spinks, Daniel, Torrie, Leah S, Thompson, Stephen, Harrison, Justin R, Frearson, Julie A, Read, Kevin D, Fairlamb, Alan H, Wyatt, Paul G, Gilbert, Ian H
Argitaratua 2012

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

nork Tardif, Steve, Madamidola, Oladipo A., Brown, Sean G., Frame, Lorna, Lefièvre, Linda, Wyatt, Paul G., Barratt, Christopher L.R., Martins Da Silva, Sarah J.
Argitaratua izan da Hum Reprod (2014)

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

nork Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Argitaratua 2011

Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

nork Murugesan, Dinakaran, Kaiser, Marcel, White, Karen L, Norval, Suzanne, Riley, Jennifer, Wyatt, Paul G, Charman, Susan A, Read, Kevin D, Yeates, Clive, Gilbert, Ian H
Argitaratua 2013

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS

nork Torrie, Leah S., Wyllie, Susan, Spinks, Daniel, Oza, Sandra L., Thompson, Stephen, Harrison, Justin R., Gilbert, Ian H., Wyatt, Paul G., Fairlamb, Alan H., Frearson, Julie A.
Argitaratua 2009

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

nork Spinks, Daniel, Shanks, Emma J, Cleghorn, Laura A T, McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H
Argitaratua 2009

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Le...

nork Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A T, Ojo, Kayode K, Van Voorhis, Wesley C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
Argitaratua 2013

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

nork Pizarro, Juan Carlos, Hills, Tanya, Senisterra, Guillermo, Wernimont, Amy K., Mackenzie, Claire, Norcross, Neil R., Ferguson, Michael A. J., Wyatt, Paul G., Gilbert, Ian H., Hui, Raymond
Argitaratua 2013

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

nork Thomas, Michael G., De Rycker, Manu, Cotillo Torrejon, Ignacio, Thomas, John, Riley, Jennifer, Spinks, Daniel, Read, Kevin D., Miles, Tim J., Gilbert, Ian H., Wyatt, Paul G.
Argitaratua izan da Bioorg Med Chem Lett (2018)

Quinol derivatives as potential trypanocidal agents

nork Capes, Amy, Patterson, Stephen, Wyllie, Susan, Hallyburton, Irene, Collie, Iain T., McCarroll, Andrew J., Stevens, Malcolm F.G., Frearson, Julie A., Wyatt, Paul G., Fairlamb, Alan H., Gilbert, Ian H.
Argitaratua 2012

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

nork De Rycker, Manu, Hallyburton, Irene, Thomas, John, Campbell, Lorna, Wyllie, Susan, Joshi, Dhananjay, Cameron, Scott, Gilbert, Ian H., Wyatt, Paul G., Frearson, Julie A., Fairlamb, Alan H., Gray, David W.
Argitaratua 2013

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

nork De Rycker, Manu, Hallyburton, Irene, Thomas, John, Campbell, Lorna, Wyllie, Susan, Joshi, Dhananjay, Cameron, Scott, Gilbert, Ian H., Wyatt, Paul G., Frearson, Julie A., Fairlamb, Alan H., Gray, David W.
Argitaratua izan da Antimicrob Agents Chemother (2014)