Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

Better drugs are urgently needed for the treatment of African sleeping sickness. We tested a series of promising anticancer agents belonging to the 4-substituted 4-hydroxycyclohexa-2,5-dienones class (“quinols”) and identified several with potent trypanocidal activity (EC(50) < 100 nm). In mammal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: König, Janine, Wyllie, Susan, Wells, Geoffrey, Stevens, Malcolm F., Wyatt, Paul G., Fairlamb, Alan H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Metabolism
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048735/
https://ncbi.nlm.nih.gov/pubmed/21212280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214833
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