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Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome

Trypanothione plays a pivotal role in defence against chemical and oxidant stress, thiol redox homoeostasis, ribonucleotide metabolism and drug resistance in parasitic kinetoplastids. In Trypanosoma brucei, trypanothione is synthesized from glutathione and spermidine by a single enzyme, TryS (trypan...

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Main Authors: Ariyanayagam, Mark R., Oza, Sandra L., Guther, Maria Lucia S., Fairlamb, Alan H.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276942/
https://ncbi.nlm.nih.gov/pubmed/16008527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050911
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