Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome

Trypanothione plays a pivotal role in defence against chemical and oxidant stress, thiol redox homoeostasis, ribonucleotide metabolism and drug resistance in parasitic kinetoplastids. In Trypanosoma brucei, trypanothione is synthesized from glutathione and spermidine by a single enzyme, TryS (trypan...

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Bibliographic Details
Main Authors: Ariyanayagam, Mark R., Oza, Sandra L., Guther, Maria Lucia S., Fairlamb, Alan H.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276942/
https://ncbi.nlm.nih.gov/pubmed/16008527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050911
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