Lataa...
Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism
Better drugs are urgently needed for the treatment of African sleeping sickness. We tested a series of promising anticancer agents belonging to the 4-substituted 4-hydroxycyclohexa-2,5-dienones class (“quinols”) and identified several with potent trypanocidal activity (EC(50) < 100 nm). In mammal...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2011
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048735/ https://ncbi.nlm.nih.gov/pubmed/21212280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214833 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|