A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes

Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-C...

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Main Authors: Galvin, Brendan D., Li, Zhiru, Villemaine, Estelle, Poole, Catherine B., Chapman, Melissa S., Pollastri, Michael P., Wyatt, Paul G., Carlow, Clotilde K. S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154664/
https://ncbi.nlm.nih.gov/pubmed/25188325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003145
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