Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

par Holloway, Georgina A., Baell, Jonathan B., Fairlamb, Alan H., Novello, Patrizia M., Parisot, John P., Richardson, John, Watson, Keith G., Street, Ian P.
Publié 2006

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

par Willoughby, Lee F., Schlosser, Tanja, Manning, Samuel A., Parisot, John P., Street, Ian P., Richardson, Helena E., Humbert, Patrick O., Brumby, Anthony M.
Publié 2013

Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library

par Lackovic, Kurt, Parisot, John P., Sleebs, Nerida, Baell, Jonathan B., Debien, Laurent, Watson, Keith G., Curtis, Joan M., Handman, Emanuela, Street, Ian P., Kedzierski, Lukasz
Publié 2010

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

par Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Publié 2011

Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

par Holloway, Georgina A., Charman, William N., Fairlamb, Alan H., Brun, Reto, Kaiser, Marcel, Kostewicz, Edmund, Novello, Patrizia M., Parisot, John P., Richardson, John, Street, Ian P., Watson, Keith G., Baell, Jonathan B.
Publié 2009

Fragment screening for a protein-protein interaction inhibitor to WDR5

par Dennis, Matthew L., Morrow, Benjamin J., Dolezal, Olan, Cuzzupe, Anthony N., Stupple, Alexandra E., Newman, Janet, Bentley, John, Hattarki, Meghan, Nuttall, Stewart D., Foitzik, Richard C., Street, Ian P., Stupple, Paul A., Monahan, Brendon J., Peat, Thomas. S.
Publié dans Struct Dyn (2019)