Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library

The current treatment for leishmaniasis is based on chemotherapy, which relies on a handful of drugs with serious limitations, such as high cost, toxicity, and a lack of efficacy in regions of endemicity. Therefore, the development of new, effective, and affordable antileishmanial drugs is a global...

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Bibliographische Detailangaben
Hauptverfasser: Lackovic, Kurt, Parisot, John P., Sleebs, Nerida, Baell, Jonathan B., Debien, Laurent, Watson, Keith G., Curtis, Joan M., Handman, Emanuela, Street, Ian P., Kedzierski, Lukasz
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Susceptibility
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863604/
https://ncbi.nlm.nih.gov/pubmed/20160053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01634-09
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