An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enteroc...

Por Johnson, Brendan M., Charman, William N., Porter, Christopher J. H.
Publicado em 2002

Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Por Persson, Linda C., Porter, Christopher J. H., Charman, William N., Bergström, Christel A. S.
Publicado em 2013

Pharmacy Education in the Context of Australian Practice

Por Marriott, Jennifer L., Nation, Roger L., Roller, Louis, Costelloe, Marian, Galbraith, Kirstie, Stewart, Peter, Charman, William N
Publicado em 2008

A Mouse Model to Evaluate the Impact of Species, Sex, and Lipid Load on Lymphatic Drug Transport

Por Trevaskis, Natalie L., Caliph, Suzanne M., Nguyen, Gary, Tso, Patrick, Charman, William N., Porter, Christopher J. H.
Publicado em 2013

Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

Por Creek, Darren J., Charman, William N., Chiu, Francis C. K., Prankerd, Richard J., Dong, Yuxiang, Vennerstrom, Jonathan L., Charman, Susan A.
Publicado em 2008

Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin

Por Creek, Darren J., Ryan, Eileen, Charman, William N., Chiu, Francis C. K., Prankerd, Richard J., Vennerstrom, Jonathan L., Charman, Susan A.
Publicado em 2009

New Manzamine Alkaloids from an Indo-Pacific Sponge. Pharmacokinetics, Oral Availability, and the Significant Activity of Several Manzamines against HIV-I, AIDS Opportunistic Infec...

Por Yousaf, Muhammad, Hammond, Nicholas L., Peng, Jiangnan, Wahyuono, Subagus, McIntosh, Kylie A., Charman, William N., Mayer, Alejandro M. S., Hamann, Mark T.
Publicado no J Med Chem (2004)

Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

Por Holloway, Georgina A., Charman, William N., Fairlamb, Alan H., Brun, Reto, Kaiser, Marcel, Kostewicz, Edmund, Novello, Patrizia M., Parisot, John P., Richardson, John, Street, Ian P., Watson, Keith G., Baell, Jonathan B.
Publicado em 2009

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with anti-malarial activity in mice

Por Gujjar, Ramesh, Marwaha, Alka, El Mazouni, Farah, White, John, White, Karen L., Creason, Sharon, Shackleford, David M., Baldwin, Jeffrey, Charman, William N., Buckner, Frederick S, Charman, Susan, Rathod, Pradipsinh K., Phillips, Margaret A.
Publicado em 2009

Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Por Gujjar, Ramesh, Mazouni, Farah El, White, Karen L., White, John, Creason, Sharon, Shackleford, David M., Deng, Xiaoyi, Charman, William N., Bathurst, Ian, Burrows, Jeremy, Floyd, David M., Matthews, David, Buckner, Frederick S., Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Publicado em 2011

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants

Por Rueda, Patricia, Harley, Elizabeth, Lu, Yao, Stewart, Gregory D., Fabb, Stewart, Diepenhorst, Natalie, Cremers, Béatrice, Rouillon, Marie-Hélène, Wehrle, Isabelle, Geant, Anne, Lamarche, Gwladys, Leach, Katie, Charman, William N., Christopoulos, Arthur, Summers, Roger J., Sexton, Patrick M., Langmead, Christopher J.
Publicado no PLoS One (2016)

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Por Yuthavong, Yongyuth, Tarnchompoo, Bongkoch, Vilaivan, Tirayut, Chitnumsub, Penchit, Kamchonwongpaisan, Sumalee, Charman, Susan A., McLennan, Danielle N., White, Karen L., Vivas, Livia, Bongard, Emily, Thongphanchang, Chawanee, Taweechai, Supannee, Vanichtanankul, Jarunee, Rattanajak, Roonglawan, Arwon, Uthai, Fantauzzi, Pascal, Yuvaniyama, Jirundon, Charman, William N., Matthews, David
Publicado em 2012

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Por Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L.
Publicado em 2011

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate p...

Por Coteron, Jose M., Marco, María, Esquivias, Jorge, Deng, Xiaoyi, White, Karen L., White, John, Koltun, Maria, Mazouni, Farah El, Kokkonda, Sreekanth, Katneni, Kasiram, Bhamidipati, Ravi, Shackleford, David M., Barturen, Iñigo Angulo, Ferrer, Santiago B., Jiménez-Díaz, María Belén, Gamo, Francisco-Javier, Goldsmith, Elizabeth J., Charman, William N., Bathurst, Ian, Floyd, David, Matthews, David, Burrows, Jeremy N., Rathod, Pradipsinh K., Charman, Susan A., Phillips, Margaret A.
Publicado em 2011