Conflicting Requirements of Plasmodium falciparum Dihydrofolate Reductase Mutations Conferring Resistance to Pyrimethamine-WR99210 Combination

Por Japrung, Deanpen, Leartsakulpanich, Ubolsree, Chusacultanachai, Sudsanguan, Yuthavong, Yongyuth
Publicado em 2007

Artemisinin effectiveness in erythrocyte is reduced by heme and heme-containing proteins

Por Ponmee, Napawan, Chuchue, Tatsanee, Wilairat, Prapon, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee
Publicado em 2007

Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen

Por Chitnumsub, Penchit, Yuvaniyama, Jirundon, Chahomchuen, Thippayarat, Vilaivan, Tirayut, Yuthavong, Yongyuth
Publicado em 2009

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model

Por Tipsuwan, Wachiraporn, Srichairatanakool, Somdet, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth, Uthaipibull, Chairat
Publicado em 2011

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization

Por Pornthanakasem, Wichai, Kongkasuriyachai, Darin, Uthaipibull, Chairat, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Publicado em 2012

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

Por Sirawaraporn, Worachart, Sathitkul, Tanajit, Sirawaraporn, Rachada, Yuthavong, Yongyuth, Santi, Daniel V.
Publicado em 1997

Evaluation of the Activities of Pyrimethamine Analogs against Plasmodium vivax and Plasmodium falciparum Dihydrofolate Reductase-Thymidylate Synthase Using In Vitro Enzyme Inhibiti...

Por Bunyarataphan, Sasinee , Leartsakulpanich, Ubolsree, Taweechai, Supannee, Tarnchompoo, Bongkoch, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth
Publicado em 2006

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

Por Somsak, Voravuth, Uthaipibull, Chairat, Prommana, Parichat, Srichairatanakool, Somdet, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee
Publicado em 2011

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene

Por Tirakarn, Srisuda, Riangrungroj, Pinpunya, Kongsaeree, Palangpon, Imwong, Mallika, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Publicado em 2012

Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay

Por Sopitthummakhun, Kittipat, Thongpanchang, Chawanee, Vilaivan, Tirayut, Yuthavong, Yongyuth, Chaiyen, Pimchai, Leartsakulpanich, Ubolsree
Publicado em 2012

Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil

Por Vanichtanankul, Jarunee, Taweechai, Supannee, Uttamapinant, Chayasith, Chitnumsub, Penchit, Vilaivan, Tirayut, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee
Publicado em 2012

Crystal structure of dihydrofolate reductase from Plasmodium vivax: Pyrimethamine displacement linked with mutation-induced resistance

Por Kongsaeree, Palangpon, Khongsuk, Puttapol, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Tarnchompoo, Bongkoch, Walkinshaw, Malcolm D., Yuthavong, Yongyuth
Publicado em 2005

Role of Plasmodium vivax Dihydropteroate Synthase Polymorphisms in Sulfa Drug Resistance

Por Pornthanakasem, Wichai, Riangrungroj, Pinpunya, Chitnumsub, Penchit, Ittarat, Wanwipa, Kongkasuriyachai, Darin, Uthaipibull, Chairat, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Publicado no Antimicrob Agents Chemother (2016)

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I

Por Kümpornsin, Krittikorn, Kotanan, Namfon, Chobson, Pornpimol, Kochakarn, Theerarat, Jirawatcharadech, Piyaporn, Jaru-ampornpan, Peera, Yuthavong, Yongyuth, Chookajorn, Thanat
Publicado em 2014

Inducible Knockdown of Plasmodium Gene Expression Using the glmS Ribozyme

Por Prommana, Parichat, Uthaipibull, Chairat, Wongsombat, Chayaphat, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth, Knuepfer, Ellen, Holder, Anthony A., Shaw, Philip J.
Publicado em 2013

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

Por Chitnumsub, Penchit, Ittarat, Wanwipa, Jaruwat, Aritsara, Noytanom, Krittikar, Amornwatcharapong, Watcharee, Pornthanakasem, Wichai, Chaiyen, Pimchai, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Publicado em 2014

Kinetic Mechanism and the Rate-limiting Step of Plasmodium vivax Serine Hydroxymethyltransferase

Por Maenpuen, Somchart, Amornwatcharapong, Watcharee, Krasatong, Pasupat, Sucharitakul, Jeerus, Palfey, Bruce A., Yuthavong, Yongyuth, Chitnumsub, Penchit, Leartsakulpanich, Ubolsree, Chaiyen, Pimchai
Publicado no J Biol Chem (2015)

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates

Por Ganesan, Karthikeyan, Ponmee, Napawan, Jiang, Lei, Fowble, Joseph W., White, John, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth, Wilairat, Prapon, Rathod, Pradipsinh K.
Publicado em 2008

Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Por Shaw, Philip J., Chaotheing, Sastra, Kaewprommal, Pavita, Piriyapongsa, Jittima, Wongsombat, Chayaphat, Suwannakitti, Nattida, Koonyosying, Pongpisid, Uthaipibull, Chairat, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee
Publicado no BMC Genomics (2015)

Exploiting Structural Analysis, In Silico Screening and Serendipity to Identify Novel Inhibitors of Drug-resistant Falciparum Malaria

Por Dasgupta, Tina, Chitnumsub, Penchit, Maneeruttanarungroj, Cherdsak, Kamchonwongpaisan, Sumalee, Nichols, Sara E., Lyons, Theresa M., Tirado-Rives, Julian, Jorgensen, William L., Yuthavong, Yongyuth, Anderson, Karen S.
Publicado em 2009