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Kinetic Mechanism and the Rate-limiting Step of Plasmodium vivax Serine Hydroxymethyltransferase
Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes a hydroxymethyl group transfer from l-serine to tetrahydrofolate (H(4)folate) to yield glycine and 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate). SHMT is crucial for deoxythymidylate biosynth...
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| Publicado en: | J Biol Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375514/ https://ncbi.nlm.nih.gov/pubmed/25678710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612275 |
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