Kinetic Mechanism and the Rate-limiting Step of Plasmodium vivax Serine Hydroxymethyltransferase

Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes a hydroxymethyl group transfer from l-serine to tetrahydrofolate (H(4)folate) to yield glycine and 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate). SHMT is crucial for deoxythymidylate biosynth...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Maenpuen, Somchart, Amornwatcharapong, Watcharee, Krasatong, Pasupat, Sucharitakul, Jeerus, Palfey, Bruce A., Yuthavong, Yongyuth, Chitnumsub, Penchit, Leartsakulpanich, Ubolsree, Chaiyen, Pimchai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375514/
https://ncbi.nlm.nih.gov/pubmed/25678710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612275
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