The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

Plasmodium falciparum serine hydroxymethyltransferase (PfSHMT), an enzyme in the dTMP synthesis cycle, is an antimalarial target because inhibition of its expression or function has been shown to be lethal to the parasite. As the wild-type enzyme could not be crystallized, protein engineering of res...

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Bibliografske podrobnosti
Main Authors: Chitnumsub, Penchit, Ittarat, Wanwipa, Jaruwat, Aritsara, Noytanom, Krittikar, Amornwatcharapong, Watcharee, Pornthanakasem, Wichai, Chaiyen, Pimchai, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2014
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051499/
https://ncbi.nlm.nih.gov/pubmed/24914963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714005598
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