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The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

Plasmodium falciparum serine hydroxymethyltransferase (PfSHMT), an enzyme in the dTMP synthesis cycle, is an antimalarial target because inhibition of its expression or function has been shown to be lethal to the parasite. As the wild-type enzyme could not be crystallized, protein engineering of res...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chitnumsub, Penchit, Ittarat, Wanwipa, Jaruwat, Aritsara, Noytanom, Krittikar, Amornwatcharapong, Watcharee, Pornthanakasem, Wichai, Chaiyen, Pimchai, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: International Union of Crystallography 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051499/
https://ncbi.nlm.nih.gov/pubmed/24914963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714005598
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