Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control

Plasmodium parasites, the causative agent of malaria, rely heavily on de novo folate biosynthesis, and the enzymes in this pathway have therefore been explored extensively for antimalarial development. Serine hydroxymethyltransferase (SHMT) from Plasmodium spp., an enzyme involved in folate recyclin...

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Udgivet i:Acta Crystallogr D Biol Crystallogr
Main Authors: Chitnumsub, Penchit, Jaruwat, Aritsara, Riangrungroj, Pinpunya, Ittarat, Wanwipa, Noytanom, Krittikar, Oonanant, Worrapoj, Vanichthanankul, Jarunee, Chuankhayan, Phimonphan, Maenpuen, Somchart, Chen, Chun-Jung, Chaiyen, Pimchai, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2014
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257618/
https://ncbi.nlm.nih.gov/pubmed/25478836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714023128
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