A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release

Human cytosolic serine hydroxymethyltransferase (hcSHMT) is a promising target for anticancer chemotherapy and contains a flexible “flap motif” whose function is yet unknown. Here, using size-exclusion chromatography, analytical ultracentrifugation, small-angle X-ray scattering (SAXS), molecular dyn...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ubonprasert, Sakunrat, Jaroensuk, Juthamas, Pornthanakasem, Wichai, Kamonsutthipaijit, Nuntaporn, Wongpituk, Peerapong, Mee-udorn, Pitchayathida, Rungrotmongkol, Thanyada, Ketchart, Onuma, Chitnumsub, Penchit, Leartsakulpanich, Ubolsree, Chaiyen, Pimchai, Maenpuen, Somchart
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615694/
https://ncbi.nlm.nih.gov/pubmed/31118236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007454
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