Role of Plasmodium vivax Dihydropteroate Synthase Polymorphisms in Sulfa Drug Resistance

Dihydropteroate synthase (DHPS) is a known sulfa drug target in malaria treatment, existing as a bifunctional enzyme together with hydroxymethyldihydropterin pyrophosphokinase (HPPK). Polymorphisms in key residues of Plasmodium falciparum DHPS (PfDHPS) have been characterized and linked to sulfa dru...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Pornthanakasem, Wichai, Riangrungroj, Pinpunya, Chitnumsub, Penchit, Ittarat, Wanwipa, Kongkasuriyachai, Darin, Uthaipibull, Chairat, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958149/
https://ncbi.nlm.nih.gov/pubmed/27161627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01835-15
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