Crystal structure of dihydrofolate reductase from Plasmodium vivax: Pyrimethamine displacement linked with mutation-induced resistance

Pyrimethamine (Pyr) targets dihydrofolate reductase of Plasmodium vivax (PvDHFR) as well as other malarial parasites, but its use as antimalarial is hampered by the widespread high resistance. Comparison of the crystal structures of PvDHFR from wild-type and the Pyr-resistant (SP21, Ser-58 → Arg + S...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kongsaeree, Palangpon, Khongsuk, Puttapol, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Tarnchompoo, Bongkoch, Walkinshaw, Malcolm D., Yuthavong, Yongyuth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2005
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201571/
https://ncbi.nlm.nih.gov/pubmed/16135570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501747102
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