Crystal structure of dihydrofolate reductase from Plasmodium vivax: Pyrimethamine displacement linked with mutation-induced resistance

Pyrimethamine (Pyr) targets dihydrofolate reductase of Plasmodium vivax (PvDHFR) as well as other malarial parasites, but its use as antimalarial is hampered by the widespread high resistance. Comparison of the crystal structures of PvDHFR from wild-type and the Pyr-resistant (SP21, Ser-58 → Arg + S...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kongsaeree, Palangpon, Khongsuk, Puttapol, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Tarnchompoo, Bongkoch, Walkinshaw, Malcolm D., Yuthavong, Yongyuth
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2005
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201571/
https://ncbi.nlm.nih.gov/pubmed/16135570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501747102
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