Crystal structure of dihydrofolate reductase from Plasmodium vivax: Pyrimethamine displacement linked with mutation-induced resistance

Pyrimethamine (Pyr) targets dihydrofolate reductase of Plasmodium vivax (PvDHFR) as well as other malarial parasites, but its use as antimalarial is hampered by the widespread high resistance. Comparison of the crystal structures of PvDHFR from wild-type and the Pyr-resistant (SP21, Ser-58 → Arg + S...

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Bibliographic Details
Main Authors: Kongsaeree, Palangpon, Khongsuk, Puttapol, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Tarnchompoo, Bongkoch, Walkinshaw, Malcolm D., Yuthavong, Yongyuth
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201571/
https://ncbi.nlm.nih.gov/pubmed/16135570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501747102
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